Journal of Data Science and Information Technology
https://jdit.sciforce.org/JDIT
<p>Shaping the Future with Data: Journal of Data Science and Information Technology (JDIT) by Sciforce Publications</p> <p>Enter the world of data-driven innovation and information technology with the Journal of Data Science and Information Technology (JDIT), a distinguished publication by Sciforce Publications. JDIT serves as a beacon for the latest research and innovations in the fields of data science, information technology, and the digital transformation of industries. In this web content, we will explore the significance of JDIT, its contributions to the scientific community, and the dynamic realm of data science and information technology.</p>Sciforce Publicationsen-USJournal of Data Science and Information Technology2998-3592Data Science Applications in Bioinformatics for Genetic Sequencing of COVID Mutations
https://jdit.sciforce.org/JDIT/article/view/233
<p>This manuscript explores the integration of data science methodologies into bioinformatics for the comprehensive analysis of genetic sequencing data related to COVID-19. Leveraging advanced computational approaches, we showcase the diverse applications of data science in unraveling the complexities of SARS-CoV-2 mutations. The presented methods and results underscore the significance of a multidisciplinary approach in understanding the genomic landscape of the virus.</p> <p>Genomic sequences of SARS-CoV-2 were obtained from diverse sources, creating a rich and extensive dataset. Data preprocessing involved quality control and feature engineering to prepare the data for subsequent analyses. Unsupervised clustering techniques and machine learning models, including Random Forest and Gradient Boosting, were applied to discern mutation patterns and predict the functional impact of mutations. The integration of network analysis further extended the exploration into protein-protein interactions and epidemiological dynamics associated with genetic mutations.</p> <p>Clustering analyses unveiled distinct mutation patterns within the SARS-CoV-2 genome, providing insights into genomic regions susceptible to mutations and potential hotspots for adaptive evolution. Predictive modeling demonstrated robust capabilities in determining the functional impact of mutations, guiding potential therapeutic interventions. Network analysis, both in the context of protein interactions and epidemiological dynamics, offered a holistic understanding of the interplay between viral genetics and disease spread.</p> <p>The results presented herein showcase the versatility of data science applications in bioinformatics for genetic sequencing of COVID mutations. By employing a multidisciplinary approach, encompassing clustering, machine learning, and network analyses, this study contributes to a nuanced understanding of the genomic landscape of SARS-CoV-2. The findings hold implications for therapeutic development, public health strategies, and our broader efforts to combat the ongoing COVID-19 pandemic.</p>Satya Sukumar MakkapatiKrishnamoorthy SelvarajSeetaram RayaraoSurya Rao RayaraoDr. Suryakiran Navath, Ph.D.
Copyright (c) 2024 Journal of Data Science and Information Technology
2024-01-042024-01-04111410.55124/jdit.v1i1.233Computational Molecular Biology in Data Science Applications on Bioinformatics in Genetic Sequencing of COVID Mutations
https://jdit.sciforce.org/JDIT/article/view/234
<p>This manuscript explores the intersection of computational molecular biology and data science in the analysis of SARS-CoV-2 genetic sequencing data. Leveraging advanced computational methods, we present a comprehensive examination of COVID-19 mutations, combining molecular insights with data-driven approaches. The integration of these disciplines contributes to a deeper understanding of the virus's genomic landscape and its implications for public health.</p> <p>Genomic sequences of SARS-CoV-2 were subjected to cutting-edge computational molecular biology techniques, including sequence alignment, variant calling, and molecular dynamics simulations. These methods provided a detailed examination of genetic variations and structural consequences associated with COVID-19 mutations. Concurrently, data science methodologies were employed for feature extraction, engineering, and the development of predictive models to discern functional outcomes.</p> <p>Molecular dynamics simulations revealed distinct structural changes correlated with specific mutations, particularly in the spike protein's receptor-binding domain. Supervised machine learning models demonstrated high accuracy in predicting the functional impact of mutations, emphasizing key genomic positions crucial for viral fitness and transmissibility. Network analysis unveiled central genes and pathways influenced by mutations, providing insights into potential drug targets and therapeutic interventions.</p> <p>The integration of computational molecular biology and data science represents a paradigm shift in our approach to understanding COVID-19 mutations. By combining molecular dynamics insights with predictive modeling and network analysis, this research contributes a holistic perspective on SARS-CoV-2 evolution. The multidisciplinary findings underscore the potential for targeted interventions and inform evidence-based public health strategies in the ongoing battle against the pandemic.</p>Krishnamoorthy SelvarajSatya Sukumar MakkapatiSurya Rao RayaraoDr. Suryakiran Navath, Ph.DSeetaram Rayarao
Copyright (c) 2024 Journal of Data Science and Information Technology
2024-01-042024-01-04115910.55124/jdit.v1i1.234